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  • Title: Nickel-catalyzed reductive methylation of alkyl halides and acid chlorides with methyl p-tosylate.
    Author: Liang Z, Xue W, Lin K, Gong H.
    Journal: Org Lett; 2014 Nov 07; 16(21):5620-3. PubMed ID: 25333482.
    Abstract:
    Methylation of unactivated alkyl halides and acid chlorides under Ni-catalyzed reductive coupling conditions led to efficient formation of methylated alkanes and ketones using methyl p-methyl tosylate as the methylation reagent. Moderate to excellent coupling yields as well as excellent functional group tolerance were observed under the present mild and easy-to-operate reaction conditions.
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