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  • Title: Metal-free oxidative radical addition of carbonyl compounds to α,α-diaryl allylic alcohols: synthesis of highly functionalized ketones.
    Author: Chu XQ, Meng H, Zi Y, Xu XP, Ji SJ.
    Journal: Chemistry; 2014 Dec 15; 20(51):17198-206. PubMed ID: 25339553.
    Abstract:
    A metal-free direct alkylation of simple carbonyl compounds (ketones, esters, and amides) with α,α-diaryl allylic alcohols is described. The protocol provides facile access to highly functionalized dicarbonyl ketones by a radical addition/1,2-aryl migration cascade. The regioselectivity of the reaction was precisely controlled by the nature of the carbonyl compound.
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