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  • Title: Co-existence of N. gonorrhoeae and U. urealyticum in male urethra.
    Author: Deodhar L, Sonawala M, Gogate A.
    Journal: J Postgrad Med; 1989 Jul; 35(3):144-6. PubMed ID: 2534520.
    Abstract:
    Eight hundred and forty male patients attending sexually transmitted disease (STD) clinic for urethritis were investigated. Out of them, 31.6% had gonococcal urethritis, 16.1% suffered from nongonococcal urethritis due to Ureaplasma urealyticum and in 12.6%, both the organisms were present. Though 14.62% strains of N. Gonorrhoeae were resistant to penicillin, all the strains were sensitive to spectinomycin; while all Ureaplasma strains were sensitive to tetracyclines. As the treatment differs for these two organisms, it is necessary to identify the correct etiological agent. The results of a study of 840 men aged 15-55 with urethritis attending a sexually transmitted disease clinic of a general hospital were that 31.6% had cultures isolated for N. gonorrhoeae, 16.1% for U. urealyticum, and 12.6% for both organisms. Bacteria were identified with the standard procedures of Finegold and Martin, and antimicrobial susceptibility testing was described by Cruickshank et al. The presence of microplasmas in patients with N. gonorrhoeae has been found in other investigations. Shepard et al. reported an association in 11.5% of patients compared with the 12.6% reported in this study, although other higher rates have been reported. There is morphological evidence that T strain mycoplasmas attach to cell wall projections on the surface of gonococci, and multiplication and viability are encouraged. Treatment involves penicillin or spectinomycin for gonococcal urethritis and tetracycline for U. urealyticum urethritis, thereby warranting differentiating the strains.
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