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  • Title: [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne].
    Author: Giannotti B.
    Journal: G Ital Dermatol Venereol; 1989 Oct; 124(10):471-7. PubMed ID: 2534552.
    Abstract:
    20% azelaic acid cream was compared clinically with its vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne. It was found that the azelaic acid treatment significantly reduced inflamed and non-inflamed lesions and yielded clinically relevant improvement rates. Its action was significantly more effective than its vehicle. In the study of comedo acne, 20% azelaic acid cream was equally effective as 0.05% tretinoin cream in reducing the number of comedones and with respect to overall response. However azelaic acid cream was better tolerated, causing fewer local side effects than the tretinoin.
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