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  • Title: Lewis base-promoted rearrangement of allylic cyanohydrins: construction of functionalized nitriles bearing 1,3-diketone moieties.
    Author: Zhang YJ, Hou QL, Wang HJ, Liao WW.
    Journal: J Org Chem; 2014 Nov 21; 79(22):10890-8. PubMed ID: 25346232.
    Abstract:
    A novel Lewis base-promoted rearrangement of allylic cyanohydrins has been developed, in which the cyano group was rearranged, directly coupled with the generation of new functional groups. This protocol provides a unique and facile way to prepare highly functionalized nitriles bearing 1,3-diketone moieties under mild reaction conditions. Furthermore, the synthetic transformations of the functionalized products have also been demonstrated.
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