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  • Title: [Clinical and monitoring experience of isotretinoin in Italy].
    Author: Cavicchini S, Bottoni A, Caputo R.
    Journal: G Ital Dermatol Venereol; 1989; 124(11-12):LXXI-LXXVII. PubMed ID: 2534717.
    Abstract:
    We report the results of a multicentric evaluation on effectiveness and safety of isotretinoin in severe acne, recalcitrant to traditional treatments. 208 patients, suffering especially from cystic acne, have been enrolled in a post-marketing clinical trial in 11 Dermatological Italian Departments. The clinical effectiveness of isotretinoin has been very good in 77% of patients, good in 16% and sufficient in 4%. The tolerability of the drug was considered good in 90% of patients. Finally, isotretinoin might be considered as one of the most effective drugs in the therapy of severe forms of acne, resistant to usual treatment, and often affecting patients on the physical and psychological side.
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