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  • Title: How D-dimer assay can be useful in deciding the duration of anticoagulation after venous thromboembolism: a review.
    Author: Palareti G.
    Journal: Expert Rev Hematol; 2015 Feb; 8(1):79-88. PubMed ID: 25348806.
    Abstract:
    Venous thromboembolism has a relatively strong tendency to recur, especially when the event is unprovoked. In this case, the duration of anticoagulation should not be shorter than 3 months, but it is also suggested to be indefinite. The decision to discontinue or extend indefinitely anticoagulation is not easy. D-dimer assay has a predictive value for individual risk of recurrence and can therefore be used in the decision-making process regarding duration of anticoagulation. This article reviews studies on D-dimer measurement as a predictor of the recurrence risk and analyzes the results of a very recent clinical study (the DULCIS study) that investigated how D-dimer assay can effectively and safely be used to decide the duration of anticoagulation in individual patients after an unprovoked event.
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