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  • Title: [Photodynamic effect of hematoporphyrin on cell organs].
    Author: Yang YZ, Fu GL, Teng SS.
    Journal: Zhongguo Yao Li Xue Bao; 1989 Nov; 10(6):554-6. PubMed ID: 2534936.
    Abstract:
    Seminiferous epithelial cells of mouse testis were treated with hematoporphyrin derivative (HPD)-light in vitro. After HPD-light treatment, the changes within cells in early stage of prophase were observed. Examination with EM showed that 30 min after HPD-light treatment, the mitochondria were aggregated and vesiculated, the nucleus showed an irregular outline and a sign of chromatolysis; the other organelles showed no significant changes at this time. The results suggest that both mitochondria and nucleus are susceptible to HPD-light treatment. Three hours after HPD-light treatment, many of multi-nucleated spermatids appeared and they all contained deformed nuclei. This fact suggests that cytokinesis was inhibited by this treatment, and the chromatin of metaphase were also damage.
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