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  • Title: Formal [4+2] annulation of enaminones and cyanomethyl sulfur ylide: one-pot access to polysubstituted pyridin-2(1H)-ones.
    Author: Zhang Q, Liu X, Xin X, Zhang R, Liang Y, Dong D.
    Journal: Chem Commun (Camb); 2014 Dec 18; 50(97):15378-80. PubMed ID: 25349951.
    Abstract:
    A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from readily available enaminones and the cyanomethyl sulfonium bromide salt in the presence of cesium carbonate is developed, and a mechanism involving sequential nucleophilic vinylic substitution (S(N)V), intramolecular nucleophilic cyclization and dealkylation reactions is proposed.
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