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  • Title: Analysis of amlodipine in serum by a sensitive high-performance liquid chromatographic method with amperometric detection.
    Author: Shimooka K, Sawada Y, Tatematsu H.
    Journal: J Pharm Biomed Anal; 1989; 7(11):1267-72. PubMed ID: 2535105.
    Abstract:
    An analytical method for a new calcium channel blocking agent, amlodipine, has been developed using high-performance liquid chromatography with electrochemical detection. No compound modification is required for detection and the calibration curve in spiked sera is linear and reproducible over the range 0.2-2.0 ng ml-1. The method has been applied successfully to pharmacokinetics studies in rats and also can be used for other dihydropyridine compounds such as nifedipine and nicardipine.
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