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  • Title: [Dependence of hypoxic changes in macro- and micro-hemodynamics on the activity of adrenoreceptors in the skeletal muscle in hypothermia].
    Author: Nurmatov AA, Kudriashov IuA, Tkachenko BI.
    Journal: Biull Eksp Biol Med; 1989 Jan; 107(1):16-9. PubMed ID: 2536567.
    Abstract:
    Dependence of hypoxic changes of macro- and microcirculation on the activity of adrenergic receptors in the cooled organism was studied on decentralized shank of cat under perfusion with constant blood flow. After cooling of cat (to 30 degrees C) and blockade of alpha-adrenoreceptors hypoxic hypoxia (10% O2 in N2) caused (a) much greater reduction of precapillary resistance of shank, (b) more striking (by 3 times) increase of capillary filtration coefficient and (c) the increase of capillary pressure and postcapillary resistance in contrast to their decrease to hypoxia under hypothermia before alpha-blockade. Beta-adrenoreceptor blockade had no influence on the changes of the resistance and exchange function of skeletal muscle blood vessels evoked by hypoxia under cooling.
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