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  • Title: [Multicenter clinical study of the antihypertensive activity of lisinopril].
    Author: Cinotti GA, Bossini A, Cagli V, Corea L, Di Veroli C, Morabito S, Pierucci A, Porcellati C, Savino K, Timio M.
    Journal: Minerva Med; 1989 Jan; 80(1):53-63. PubMed ID: 2536907.
    Abstract:
    One-hundred patients suffering from slight-moderate hypertension (53 m, 47 f, aged between 18 and 78, average 49.08) have been studied in order to assess the effectiveness and tolerance of lisinopril ("Zestril", ICI-Pharma), a new ACE inhibitor in a single daily administration at doses of between 10 and 80 mg in relation to pressure values. Monotherapy with Lisinopril proved effective in 84 patients (88.4%), in 74 of whom (7.9%) pressure values were returned to normal. 11 patients (11.6%) did not respond to treatment. In most cases, the result was obtained with a dose of 20 mg in a single administration (32.6%). The incidence of side-effects was limited and in no case required the withdrawal of the drug.
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