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  • Title: Diketopyrrolopyrrole-porphyrin conjugates with high two-photon absorption and singlet oxygen generation for two-photon photodynamic therapy.
    Author: Schmitt J, Heitz V, Sour A, Bolze F, Ftouni H, Nicoud JF, Flamigni L, Ventura B.
    Journal: Angew Chem Int Ed Engl; 2015 Jan 02; 54(1):169-73. PubMed ID: 25370127.
    Abstract:
    Two-photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two-photon absorption and singlet-oxygen generation. Reported here are two new diketopyrrolopyrrole-porphyrin conjugates as robust two-photon absorbing dyes with high two-photon absorption cross-sections within the therapeutic window. Furthermore, for the first time the singlet-oxygen generation efficiency of diketopyrrolopyrrole-containing systems is investigated. A preliminary study on cell culture showed efficient two-photon induced phototoxicity.
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