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  • Title: Polymorphonuclear leucocyte chemotaxis in response to leukotriene B4 in treated and untreated psoriatics.
    Author: Green CM, Ferguson J, MacLeod TM, Millar BW, Raffle EJ.
    Journal: Dermatologica; 1989; 178(1):20-2. PubMed ID: 2537239.
    Abstract:
    Various chemoattractants have been implicated in the aetiology of the polymorphonuclear leucocyte (PMN) migration into the epidermis seen in early lesions of psoriasis. Using an under-agarose technique, the in vitro chemotactic responses of PMN to the arachidonic acid lipoxygenase product leukotriene B4 (LTB4) were assayed in five groups of subjects: normal healthy volunteers (n = 12), untreated psoriatics (n = 11) and psoriatics treated with topical tar (n = 12), PUVA (n = 11) and UVB phototherapy (n = 10). No significant difference was observed between the responses of control subjects and of untreated psoriatics, nor between the untreated psoriatic group and the PUVA- and UVB-treated groups, respectively. However, comparison of the tar-treated and untreated groups revealed a significantly increased chemotactic response to LTB4 in the tar-treated group (p less than 0.01).
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