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  • Title: 6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA.
    Author: Tanc M, Carta F, Scozzafava A, Supuran CT.
    Journal: Org Biomol Chem; 2015 Jan 07; 13(1):77-80. PubMed ID: 25373598.
    Abstract:
    A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms. All the compounds showed excellent selectivity against the mitochondrial (hCA VA) and the tumor associated (hCA IX and XII) enzymes.
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