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  • Title: Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors.
    Author: Willcocks AL, Strupish J, Irvine RF, Nahorski SR.
    Journal: Biochem J; 1989 Jan 01; 257(1):297-300. PubMed ID: 2537626.
    Abstract:
    The activity of inositol 2,4,5-trisphosphate and inositol 1:2-cyclic,4,5-trisphosphate relative to inositol 1,4,5-trisphosphate was examined by two assays; firstly, in a binding assay using rat cerebellar membranes, and secondly, in a Ca2+-mobilization assay using permeabilized Swiss 3T3 cells. In both assays the first two phosphates have a potency at least an order of magnitude less than inositol 1,4,5-trisphosphate. The possible reasons for differences between these results and previous data are discussed, as are the implications for any putative physiological role for the cyclic trisphosphate.
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