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  • Title: Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells.
    Author: Zijlstra FJ, Wilson JH, Vermeer MA, Ouwendijk RJ, Vincent JE.
    Journal: Eur J Pharmacol; 1989 Jan 17; 159(3):291-5. PubMed ID: 2537738.
    Abstract:
    Macrophages isolated from fluids of patients with liver cirrhosis mainly generated the 5-lipoxygenase products leukotriene B4 and 5-monohydroxyeicosatetraenoic acid. The cyclooxygenase products 6-keto-PGF1 alpha and thromboxane B2 were the most important prostaglandin-like substances. Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways were stimulated. The effects of malotilate on eicosanoid production differ from those of known lipoxygenase inhibitors. Such differential effects have not been reported previously.
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