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  • Title: Effects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cells.
    Author: Szalay KS, De Wied D, Stark E.
    Journal: J Steroid Biochem; 1989 Feb; 32(2):259-62. PubMed ID: 2537913.
    Abstract:
    The steroidogenic action of ACTH-(11-24) was studied on isolated zona glomerulosa and zona fasciculata cells dispersed by collagenase. ACTH-(11-24) stimulated the corticosterone production of zona fasciculata cells and the aldosterone production of zona glomerulosa cells; in addition, it potentiated the effects of ACTH-(1-39) on both cell systems. It is suggested that the ACTH molecule contains more active sites for steroidogenesis than usually acknowledged, as has been found for lipolysis and behavior.
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