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  • Title: [Na+/H+ metabolic activity in the thrombocytes of spontaneously hypertensive rats].
    Author: Markov KhM, Pinelis VG, Kudinov IuV, Borin ML, Azizova OA.
    Journal: Biull Eksp Biol Med; 1989 Feb; 107(2):188-90. PubMed ID: 2538169.
    Abstract:
    The sodium-proton exchange was determined in platelets of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The platelets were suspended in sodium propionate; the cytoplasmic acidification activated the exchanger and intracellular pH (the increasing) and volume of the platelets (the swelling) were registered. The activity of Na+/H+ exchange was inhibited by isopropyl amiloride. The platelets' volume and the exchange rate constant of SHR were increased on 30-40% as compared with those of WKY.
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