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  • Title: Activation of ACTH release is mediated by the same molecule as the final mediator, PGE2, of febrile response in rats.
    Author: Murakami N, Watanabe T.
    Journal: Brain Res; 1989 Jan 23; 478(1):171-4. PubMed ID: 2538201.
    Abstract:
    Increase in the blood level of adrenocorticotropic hormone (ACTH) and fever are induced by i.v. administration of interleukin-1 alpha (IL-1 alpha) in rats. With preinjection of indomethacin, the ACTH and fever responses to i.v. IL-1 alpha were both either greatly reduced or abolished. Intrapreoptic microinjection of prostaglandin E2 (PGE2) caused ACTH and fever responses similar to those seen after i.v. IL-1 alpha. These data suggest that PGE2, a final mediator of fever, may be released by i.v. IL-1 alpha and also act centrally to enhance the release of corticotropic-releasing factor in the brain.
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