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  • Title: Similarities between the regulatory sequences of the unrelated tetracycline genes of pBR322 and Tn10.
    Author: Hung A, Pictet R.
    Journal: FEBS Lett; 1989 Mar 13; 245(1-2):57-60. PubMed ID: 2538364.
    Abstract:
    The regulatory regions of the tetracycline genes present in pBR322 (pSC101) and in the transposon Tn10 are compared. They show a low degree of nucleotide sequence similarity but a high level of structure similarity. Furthermore, analyses of RNAs transcribed in the opposite direction of the pBR322 tet gene show that there are two mRNA initiation sites separated by 29 nucleotides. This suggests the existence of two promoters for the tet repressor gene in Tn10. These features reveal a strong resemblance of the mode of regulation between the tet operons of Tn10 and pSC101.
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