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  • Title: Endothelin enhances adrenergic vasoconstriction in perfused rat mesenteric arteries.
    Author: Tabuchi Y, Nakamaru M, Rakugi H, Nagano M, Ogihara T.
    Journal: Biochem Biophys Res Commun; 1989 Mar 31; 159(3):1304-8. PubMed ID: 2539151.
    Abstract:
    The interaction of endothelin with alpha-adrenergic receptors was examined in isolated perfused rat mesenteric arteries. Infusion of porcine or rat endothelin increased the baseline perfusion pressure dose-dependently. Subpressor doses of both porcine (10(-11) and 10(-10)M) and rat (10(-10) and 10(-9)M) endothelin enhanced the pressor responses to norepinephrine. Nicardipine (10(-7)M), a calcium channel blocker, attenuated this potentiation. These results suggest that endothelin enhances the responsiveness of alpha-adrenergic receptors to catecholamines probably through the increase in calcium influx. Thus endothelin may interact with sympathetic nerve activity in addition to having a direct vasoconstrictor action in peripheral vascular tissue.
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