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  • Title: Mutational analysis of bovine papillomavirus E6 gene.
    Author: Vousden KH, Androphy EJ, Schiller JT, Lowy DR.
    Journal: J Virol; 1989 May; 63(5):2340-2. PubMed ID: 2539522.
    Abstract:
    The bovine papillomavirus E6 gene can independently transform mouse C127 cells. To characterize E6 in greater detail, we created 16 site-directed mutations in E6, including substitution mutations in the cysteine codons of the four Cys-X-X-Cys motifs that are conserved in all papillomavirus E6 proteins. Proteins mutated in six of the seven cysteines tested, as well as those lacking the nonconserved C-terminus, were stable in transfected cells but were unable to induce morphological transformation, indicating that these amino acids play an important role in the function of E6.
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