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  • Title: Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: randomised controlled trial.
    Author: Calver L, Drinkwater V, Gupta R, Page CB, Isbister GK.
    Journal: Br J Psychiatry; 2015 Mar; 206(3):223-8. PubMed ID: 25395689.
    Abstract:
    BACKGROUND: Agitation and aggression are significant problems in acute psychiatric units. There is little consensus on which drug is most effective and safest for sedation of these patients. AIMS: To compare the effectiveness and safety of haloperidol v. droperidol for patients with agitation and aggression. METHOD: In a masked, randomised controlled trial (ACTRN12611000565943) intramuscular droperidol (10 mg) was compared with intramuscular haloperidol (10 mg) for adult patients with acute behavioural disturbance in a psychiatric intensive care unit. The primary outcome was time to sedation within 120 min. Secondary outcomes were use of additional sedation, adverse events and staff injuries. RESULTS: From 584 patients, 110 were randomised to haloperidol and 118 to droperidol. Effective sedation occurred in 210 (92%) patients within 120 min. There was no significant difference in median time to sedation: 20 min (interquartile range 15-30, range 10-75) for haloperidol v. 25 min (IQR 15-30, range 10-115) for droperidol (P = 0.89). Additional sedation was used more often with haloperidol (13% v. 5%, P = 0.06), but adverse effects were less common with haloperidol (1% v. 5%, P = 0.12). There were 8 staff injuries. CONCLUSIONS: Both haloperidol and droperidol were effective for sedation of patients with acute behavioural disturbance.
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