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  • Title: [Effect of antimediator preparations on the intercellular relations in early embryos of the sea urchin].
    Author: Buznikov GA, Shmukler IuB.
    Journal: Ontogenez; 1978; 9(2):173-8. PubMed ID: 25400.
    Abstract:
    The dated treatment of the early embryos of an irregular (flat) sea urchin Scaphechinus mirabilis by neuropharmacological drugs (anti-neurotransmitters) during one of the first four cleavage divisions results in the impairment of intercellular connections and leads to the formation of twin embryos, dwarf embryos, embryos of the dumb-bell shape etc. In the experiments with some of the drugs under study such developmental abnormalities were not seen or were expressed much more weakly when serotonin or bufotenin (N,N-dimethylserotonin) were added to the medium. A suggestion is put forward that the early embryos possess an intracellular mechanism participating in the interaction between the cells and operating via endogenous monoamines, primarily serotonin.
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