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  • Title: Maedi-visna in sheep: host-virus interactions and utilization as a model.
    Author: Pétursson G, Pálsson PA, Georgsson G.
    Journal: Intervirology; 1989; 30 Suppl 1():36-44. PubMed ID: 2540112.
    Abstract:
    Controlled animal experiments with the ovine maedi-visna virus, the prototype lentivirus, have been carried out for almost 40 years. This non-oncogenic virus leads to a life-long, persistent infection with slow development of lesions in the lungs and in the central nervous system. The virus is present in many cells in a DNA provirus state and its replication and expression is highly restricted in vivo. The basic biological features of maedi-visna virus are quite similar to those of HIV and this ovine lentiviral disease may be useful as a model for infection with human lentiviruses.
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