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  • Title: Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F.
    Author: Korkhov VM, Mireku SA, Veprintsev DB, Locher KP.
    Journal: Nat Struct Mol Biol; 2014 Dec; 21(12):1097-9. PubMed ID: 25402482.
    Abstract:
    The reaction mechanism of BtuCD-F-catalyzed vitamin B12 transport into Escherichia coli is currently unclear. Here we present the structure of the last missing state in the form of AMP-PNP-bound BtuCD, trapped by a disulfide cross-link. Our structural and biochemical data allow a consistent mechanism to be formulated, thus rationalizing the roles of substrate, ATP and substrate-binding protein.
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