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  • Title: Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.
    Author: Lennox G, Lowe J, Morrell K, Landon M, Mayer RJ.
    Journal: J Neurol Neurosurg Psychiatry; 1989 Jan; 52(1):67-71. PubMed ID: 2540286.
    Abstract:
    Brainstem and cortical Lewy bodies in diffuse Lewy body disease show intense immunoreactivity to antibodies against ubiquitin. Quantitative studies show that the novel neuropathological technique of anti-ubiquitin immunocytochemistry is more than twice as sensitive as conventional haematoxylin and eosin stains in detecting cortical Lewy bodies. Anti-ubiquitin immunocytochemistry should be regarded as the method of choice for the diagnosis and quantification of diffuse Lewy body disease.
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