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  • Title: Modular total syntheses of the marine-derived resorcylic Acid lactones cochliomycins a and B using a late-stage nozaki-hiyama-kishi macrocyclization reaction.
    Author: Bolte B, Basutto JA, Bryan CS, Garson MJ, Banwell MG, Ward JS.
    Journal: J Org Chem; 2015 Jan 02; 80(1):460-70. PubMed ID: 25405580.
    Abstract:
    The natural products cochliomycin A (1) and cochliomycin B (2), two resorcylic acid lactones obtained from marine sources, have been prepared in a concise and stereocontrolled manner from the readily accessible building blocks 4-6. Olefin cross-metathesis, trans-esterification and Nozaki-Hiyama-Kishi (NHK) macrocyclization reactions were employed in the key steps. Hydrolysis of the immediate precursor to cochliomycin B affords the resorcylic acid lactone zeaenol (24).
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