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  • Title: Multiphenotypic lymphoma with rearrangements of the T cell receptor beta chain and gamma chain genes.
    Author: Yasukawa M, Kanemitsu N, Inatsuki A, Mise H, Iwamasa K, Fujita S.
    Journal: Acta Haematol; 1989; 81(3):143-7. PubMed ID: 2540603.
    Abstract:
    A case of chemotherapy-resistant non-Hodgkin's lymphoma simultaneously expressing T cell (CD7)-, B cell (CD19)- and myeloid (CD13, CD33)-associated surface antigens is presented. Cytochemical analysis revealed that the lymphoma cells were positive for terminal deoxynucleotidyl transferase, but negative for myeloperoxidase and esterase. Rearrangements of both the T cell receptor beta chain and gamma chain genes were observed, but the immunoglobulin genes showed a germ line configuration. The rearrangement was not detected within the breakpoint cluster region on chromosome 22. These findings are considered to represent aberrant expressions of the B cell- and myeloid-associated antigens in early-stage T cell lineage lymphoma cells.
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