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  • Title: Dual-functional probes for sequential thiol and redox homeostasis sensing in live cells.
    Author: Ma T, Ding H, Xu H, Lv Y, Liu H, Wang H, Tian Z.
    Journal: Analyst; 2015 Jan 07; 140(1):322-9. PubMed ID: 25406724.
    Abstract:
    A new type of resorufin-based dual-functional fluorescent probe whose fluorescence emission features are sensitive to thiol compounds and redox homeostasis was developed. Thiols-triggered nucleophilic substitution of the probes converts the nonfluorescent probe to the highly fluorescent resorufin moiety; the released resorufin not only enables fluorescence signaling specific for thiol compounds but functions as a redox indicator with sensitive colorimetric and fluorescence emission change upon redox variation. Preliminary fluorescence imaging experiments have revealed the biocompatibility of the as-prepared probes and validated their practicability for thiol sensing and redox homeostasis mapping in living cells.
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