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  • Title: Out of the active site binding pocket for carbonic anhydrase inhibitors.
    Author: D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G.
    Journal: Chem Commun (Camb); 2015; 51(2):302-5. PubMed ID: 25407638.
    Abstract:
    A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site.
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