These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Differentiating surface and bulk interactions in nanoplasmonic interferometric sensor arrays.
    Author: Zeng B, Gao Y, Bartoli FJ.
    Journal: Nanoscale; 2015 Jan 07; 7(1):166-70. PubMed ID: 25407985.
    Abstract:
    Detecting specific target analytes and differentiating them from interfering background effects is a crucial but challenging task in complex multi-component solutions commonly encountered in environmental, chemical, biological, and medical sensing applications. Here we present a simple nanoplasmonic interferometric sensor platform that can differentiate the adsorption of a thin protein layer on the sensor surface (surface effects) from bulk refractive index changes (interfering background effects) at a single sensing spot, exploiting the different penetration depths of multiple propagating surface plasmon polaritons excited in the ring-hole nanoplasmonic sensors. A monolayer of bovine serum albumin (BSA) molecules with an effective thickness of 1.91 nm is detected and differentiated from a 10(-3) change in refractive index unit for the bulk solution. The noise level of the retrieved real-time sensor output compares favorably with that of traditional prism-based surface plasmon resonance sensors, but is achieved using a significantly simpler collinear transmission geometry and a miniaturized sensor footprint.
    [Abstract] [Full Text] [Related] [New Search]