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  • Title: Immunologic studies of arylsulfatase A in normal and metachromatic leukodystrophy liver.
    Author: Shapira E, DeGregorio RR, Nadler HL.
    Journal: Pediatr Res; 1978 Mar; 12(3):199-203. PubMed ID: 25410.
    Abstract:
    Purified human liver arylsulfatase A on polyacrylamide gel electrophoresis at pH 4.0 is separated into two protein forms with enzymatic activity and two distinct inactive subunits. All of these components were immunologically distinguishable using different antisera preparations. In late infantile metachromatic leukodystrophy, only one of the two inactive subunits was immunologically detected, whereas in the juvenile form of metachromatic leukodystrophy, both inactive subunits were antigenically present.
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