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  • Title: Growth stimulatory effect of pancreatic spasmolytic polypeptide on cultured colon and breast tumor cells.
    Author: Hoosein NM, Thim L, Jørgensen KH, Brattain MG.
    Journal: FEBS Lett; 1989 Apr 24; 247(2):303-6. PubMed ID: 2541019.
    Abstract:
    The effects of a novel polypeptide, pancreatic spasmolytic polypeptide (PSP) on a colon carcinoma cell line (HCT 116) were examined. PSP stimulated the incorporation of [3H]thymidine into HCT 116 cells as well as cell proliferation in a dose-dependent manner. Maximal increase in [3H]thymidine incorporation of 50-60% occurred at 3-300 microM PSP. The VIP-mediated-increase in cAMP levels was reduced by PSP at greater than 1 microM concentrations. PSP is highly homologous to the estrogen-induced pS2 protein in MCF-7 breast cancer cells. We find that PSP also enhanced [3H]thymidine incorporation in MCF-7 cells. These findings indicate for the first time that PSP has growth stimulatory properties.
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