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Title: [Contact hypersensitivity (DNCB test) and inhibition by the calcium channel blocker diltiazem]. Author: Diezel W, Gruner S, Anhalt GJ, Strunk D, Shanks M, Sönnichsen N. Journal: Dermatol Monatsschr; 1989; 175(3):170-4. PubMed ID: 2541031. Abstract: We studied the influence of the calcium transport inhibitor diltiazem on epidermal Langerhans cell-induced contact dermatitis against 1-chloro-2.4-dinitrobenzene (DNCB) in Balb/c mice. Diltiazem administered systemically was found to be able to decrease allergic reactions against DNCB. Twenty four hours post challenge animals treated with diltiazem demonstrated a 36% decreased ear swelling compared with non diltiazem-treated animals (p less than 0.001). From these results, we conclude that calcium is important in regulating epidermal Langerhans cell functions and in activating these cells.[Abstract] [Full Text] [Related] [New Search]