These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension.
    Author: Cugini P, Lucia P, Letizia C, Murano G, Scavo D, Giganti G, Calogero A, Verna R.
    Journal: Enzyme; 1989; 41(3):159-67. PubMed ID: 2542013.
    Abstract:
    The Na,K-ATPase activity of erythrocyte membranes is markedly increased in normal-renin essential hypertensives. A temporal shift of the chronobiology of the erythrocyte-membrane-bound Na,K-ATPase in these patients is described. The disorder causes a loss of synchronism between the circadian rhythms of aldosterone and Na,K-ATPase. Such uncoupling phenomenon may explain the inversion of the day/night sodium excretion ratio and other disturbances of sodium metabolism found in essential hypertensives.
    [Abstract] [Full Text] [Related] [New Search]