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  • Title: [Frequency-related blocking of sodium channels in the membrane of isolated rat cardiomyocytes by the calcium antagonist verapamil].
    Author: Pidoplichko VI, Verkhratskiĭ AN.
    Journal: Fiziol Zh (1978); 1989; 35(2):87-9. PubMed ID: 2542101.
    Abstract:
    Use-dependent blocking of sodium current in the membrane of single rat cardiomyocytes by verapamil (in the concentration range of 5-50 mumol/l) has been observed. The data obtained suggest that verapamil binding with sodium channels which are in the open or inactivated state underlies suppression of sodium current.
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