These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Activation of GABAB receptors causes presynaptic inhibition at synapses between muscle spindle afferents and motoneurons in the spinal cord of bullfrogs.
    Author: Peng YY, Frank E.
    Journal: J Neurosci; 1989 May; 9(5):1502-15. PubMed ID: 2542476.
    Abstract:
    Baclofen, a specific GABAB receptor agonist, was used to study the functional role of activation of GABAB receptors in synaptic transmission between muscle spindle afferents and motoneurons in the isolated spinal cord of bullfrogs. (+/-)-Baclofen (5 microM) reversibly reduced the amplitude of the excitatory postsynaptic potential (EPSP) evoked by simulation of various brachial muscle nerves and recorded extracellularly from the ventral root by 47% without shortening the falling phase of the EPSP. Neither the time course nor the amplitude of the action potentials in the sensory afferents was affected. Thus, baclofen caused synaptic inhibition without reducing either the potential change occurring in the muscle sensory afferents or the motoneuronal membrane resistance. Quantal analysis, performed using a deconvolution technique, of the monosynaptic EPSPs in brachial motoneurons evoked by activity in single triceps muscle spindle afferents showed that transmission at these synapses was quantal, and baclofen lowered the quantal content without altering the quantal size. Furthermore, quantal analysis of the electrical component of these unitary EPSPs showed that it did not fluctuate in amplitude, either in normal saline or with baclofen. The inhibition produced by activation of GABAB receptors is therefore presynaptic but is not likely to be caused by conduction failures in the sensory terminals.
    [Abstract] [Full Text] [Related] [New Search]