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  • Title: Michaelis-Menten kinetics under non-isothermal conditions.
    Author: Lervik A, Kjelstrup S, Qian H.
    Journal: Phys Chem Chem Phys; 2015 Jan 14; 17(2):1317-24. PubMed ID: 25425022.
    Abstract:
    We extend the celebrated Michaelis-Menten kinetics description of an enzymatic reaction taking into consideration the presence of a thermal driving force. A coupling of chemical and thermal driving forces is expected from the principle of non-equilibrium thermodynamics, and specifically we obtain an additional term to the classical Michaelis-Menten kinetic equation, which describes the coupling in terms of a single parameter. A companion equation for the heat flux is also derived, which actually can exist even in the absence of a temperature difference. Being thermodynamic in nature, this result is general and independent of the detailed mechanism of the coupling. Conditions for the experimental verification of the new equation are discussed.
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