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  • Title: Vanadate counteracts glucagon effects in isolated rat hepatocytes.
    Author: Miralpeix M, Gil J, Rosa JL, Carreras J, Bartrons R.
    Journal: Life Sci; 1989; 44(20):1491-7. PubMed ID: 2542711.
    Abstract:
    The incubation of isolated rat hepatocytes with vanadate increased the concentration of fructose 2,6-bisphosphate without modifying 6-phosphofructo-2-kinase activity. Vanadate also reverted and prevented the decrease of fructose 2,6-bisphosphate levels, of the "active" form of the 6-phosphofructo 2-kinase and of the pyruvate kinase activity ratio produced by glucagon, by probably counteracting the increase in cyclic AMP concentration.
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