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  • Title: Simple way to obtain pH-sensitive drug release from functional mesoporous silica materials.
    Author: Xiang D, Lin H, Guo W, Ma J, Cui L, Jiang J, Qu F.
    Journal: IET Nanobiotechnol; 2014 Dec; 8(4):179-83. PubMed ID: 25429494.
    Abstract:
    A novel pH-sensitive drug release system has been synthesised by functional mesoporous silica materials. SBA-15, calcium modified SBA-15 (Ca-SBA-15) and phosphate modified SBA-15 (PO4-SBA-15) were synthesised using solvent evaporation method. It is a simple and feasible way to prepare the doping mesoporous silica materials. They show the large surface are, high pore volume and uniform pore size. Metformin hydrochloride was used as the model drug, and the control release behaviour was investigated. The functional mesoporous silica materials show the pH sensitive drug release behaviour because of the adjustable interaction between the drug molecule and the host.
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