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  • Title: Corticotropin-releasing hormone: clinical applications.
    Author: Nieman LK, Loriaux DL.
    Journal: Annu Rev Med; 1989; 40():331-9. PubMed ID: 2543267.
    Abstract:
    Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states. The administration of synthetic human and ovine CRH has been found useful in the differential diagnosis of Cushing's syndrome and in the preoperative localization of intrasellar ACTH-secreting tumors.
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