These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes.
    Author: Ahmad S, Seebacher W, Wolkinger V, Presser A, Faist J, Kaiser M, Brun R, Saf R, Weis R.
    Journal: Arch Pharm Res; 2015 Aug; 38(8):1455-67. PubMed ID: 25433423.
    Abstract:
    Some antimalarial agents in use typically bear basic side chains as ligands. Such ligands were attached to the amino substituent of a bridgehead atom of already antiprotozoal active 3-azabicyclo[3.2.2]nonanes. Structure verification was done by NMR measurements. The new compounds were tested for their antiplasmodial and antitrypanosomal activities against Plasmodium falciparum K 1 (multiresistant) and Trypanosoma brucei rhodesiense as well as for their cytotoxicity against L6 cells. Their activities are compared to those of already prepared compounds and structure-activity relationships are discussed.
    [Abstract] [Full Text] [Related] [New Search]