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Title: Superoxide dismutase amplifies dye photosensitized production of desferal free radical: an electron spin resonance study. Author: Li AS, de Haas AH, Chignell CF, Motten AG. Journal: Biochem Biophys Res Commun; 1989 May 15; 160(3):1055-60. PubMed ID: 2543384. Abstract: Desferal free radical (DFFR) photogenerated from dye sensitization was studied by electron spin resonance. When irradiated at the visible maximum in the presence of O2, both rose bengal and riboflavin sensitized the oxidation of Desferal (DF) and generated the DFFR. The yield of DFFR was amplified by superoxide dismutase (SOD). The SOD enhancement was attributed to the inhibition of superoxide-induced DFFR destruction. Similar SOD enhancement was observed with dyes Rhodamine 123 and Gentian Violet. Our studies suggest that when Desferal is used as a chelating agent in the presence of SOD, systems involving O2- could face interference from DFFR even at concentrations as low as 10 microM DF. DFFR may interfere with the chain reaction of lipid peroxidation resulting in an apparent protective action which, in fact, has very little to do with chelating the catalytic iron.[Abstract] [Full Text] [Related] [New Search]