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  • Title: Rsp5/Nedd4 clears cells of heat-damaged proteins.
    Author: Sommer T, Weber A, Jarosch E.
    Journal: Nat Cell Biol; 2014 Dec; 16(12):1130-2. PubMed ID: 25434464.
    Abstract:
    Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.
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