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  • Title: Antibody-dependent enhancement of yellow fever and Japanese encephalitis virus neurovirulence.
    Author: Gould EA, Buckley A.
    Journal: J Gen Virol; 1989 Jun; 70 ( Pt 6)():1605-8. PubMed ID: 2543793.
    Abstract:
    Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.
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