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  • Title: [Effects of different exercise intensity on PPARγ and relative index in adolescent obesity rats].
    Author: Li M, Bai Y, Jianfei C, Xiaodong X, Yuanyuan D, Jing Z.
    Journal: Wei Sheng Yan Jiu; 2014 Sep; 43(5):732-7. PubMed ID: 25438525.
    Abstract:
    OBJECTIVE: Discuss the effects of low, medium, high intensity exercise induced by PPAR gamma and related indexes of diet in obsess SD rats. METHODS: Male SD rats are selected to establish experimental obesity model of SD rats, selecting 32 rats of model successfully and randomly divided into control group, low intensity group, moderate intensity group and high strength group. Each exercise group is trained by treadmill training for 8 weeks. After 8 weeks, their blood and adipose tissue are collected and the body fat and blood lipid are measured. The qRT-PCR method is used to measure the expression of PPAR gamma mRNA in adipose tissue, and immunohistochemical staining method are used to measure the protein expression of PPAR gamma, and ELIASA is used to determine the plasma concentrations of PPARgamma. RESULTS: After the exercise, the exponent of rats' weight and body fat have reduced (P <0. 01), and the exponent groups of lee' s index are indiscrimination(P > 0. 05) , TC expressed as moderate intensity and high intensity decreased compared with the control group (P <0. 05). TG levels in low, medium and high intensity group are lower than those in the control group (P. < 0.01), LDL levels in medium and high intensity groups are higher than the control group (P < 0.05).The concentrations of PPAR plasma in low, medium and high intensity group are higher than in the control group (P <0.05). PPARy mRNA expression in adipose tissue of low, medium and high intensity group are enhanced than the control group. Immunohistochemical results of PPARy is in consistent with the expression of PPARgamma CONCLUSION: Method of different intensity of exercise for 8 weeks have play a significant effect on weight loss and body fat is significantly lower. Besides, it can also improve blood lipid effectively and significantly increases the expression of PPARy in plasma and adipose tissue.
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