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  • Title: Ultrasound diagnosis of carotid artery stiffness in patients with ischemic leukoaraiosis.
    Author: Turk M, Pretnar-Oblak J, Zupan M, Zvan B, Zaletel M.
    Journal: Ultrasound Med Biol; 2015 Jan; 41(1):64-71. PubMed ID: 25438859.
    Abstract:
    The pathophysiology of ischemic leukoaraiosis (ILA) is unknown. It was recently found that ILA patients have increased aortic stiffness. Carotid stiffness is a more specific parameter and could have value as a non-invasive diagnostic value for ILA. Therefore, using color-coded duplex sonography, we compared local carotid stiffness parameters of 59 patients with ILA with those of 45 well-matched controls. The diagnosis of ILA was based on exclusion of other causes of white matter changes seen on magnetic resonance imaging. Pulse wave velocity β (PWVβ, m/s), pressure-strain elasticity modulus (Ep, kPa), β index and augmentation index (Aix, %) values were higher and arterial compliance (AC, mm(2)/kPa) values were lower in the ILA group; however, only Ep and PWVβ reached statistical significance (p ≤ 0.05). β, Ep and PWVβ exhibited an increasing trend with higher Fazekas score, though only Ep reached significance (p = 0.05). The main conclusion was that Ep and PWVβ could have a diagnostic role in patients with ILA.
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