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  • Title: Primary prophylaxis of variceal bleeding.
    Author: Ilyas JA, Kanwal F.
    Journal: Gastroenterol Clin North Am; 2014 Dec; 43(4):783-94. PubMed ID: 25440925.
    Abstract:
    Gastroesophageal varices are present in almost half of patients with cirrhosis at the time of initial diagnosis. Variceal bleeding occurs in 25% to 35% of patients with cirrhosis. Effective and timely care can prevent variceal bleeding (primary prophylaxis). For example, clinical studies demonstrate that both beta-blockers and endoscopic variceal ligation are effective in preventing a first episode of variceal bleeding. The major challenge is to screen patients in a timely manner and institute a form of therapy that has the highest chance of success in terms of patient compliance and effectiveness.
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